The interplay between the kidneys, cardiovascular system, and metabolic disease is complex. The close relationship of renal function, cardiac function, and metabolic disease has given rise to the concept of cardio-renal-metabolic syndromes. This interplay extends beyond these syndromes and manifests itself in the form of hypertension, metabolic syndrome, and peripheral vascular disease. With the epidemic of diabetes and aging of the United States population, physicians will continue to face a growing number of patients with renal and cardiovascular disease. This CME program will serve to help foster education and discussion about the intersection of these three pathophysiologic systems.